The clinical interpretation of genomic variants in disease is contingent upon the accurate assessment of the variant allele frequency in the host population. The availability of genome data is largely skewed, and many populations are underrepresented in genome databases. Working with our collaborators across the world, we are investigating genome variations in diverse populations and their role in cancer. Furthermore, we are creating aggregate databases from ethnically diverse genomic data. By developing computation platforms with public web-based access, we are making these diverse data sets accessible to enhance their utility in patient care and genomic medicine.