IGP (International Genome Programs) are designed to perform advanced clinical genome interpretation using large-scale datasets and sophisticated tools across multiple institutions. The overarching goal of these programs is to develop
a systematic framework for interpreting the genomic landscape from whole genome sequencing (WGS) data to investigate the genetic etiology of disease. Using joint genome analysis of probands and unaffected family members (e.g., trio,
quad), we investigate the genomic landscape and informative de novo and inherited genetic variants. These aggregated genomic datasets provide scientifically invaluable resources that can be used to map genome variation, reveal a
spectrum of genetic variants with potential functional impact, and chart disease risk factors across diverse populations.
